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the best and safest answer when dealing with a lack of microbial balance in the intestine

Redressing the balance of intestinal flora is important
in many clinical situations:

 
    • Lack of microbial balance after antibiotic treatments
    • Lack of microbial balance due to incorrect eating habits
    • Lack of balance of vitamins and reduced intestinal absorption due to lack of microbial balance
    • Acute and chronic intestinal problems (diarrhoea, colitis, constipation, meteorism, digestive problems)
    • Dull skin colour, lack of elasticity in the skin or pimply skin caused by intestinal dysfunction
    • Cystitis
    •  Regulation of the immune responses
 

capsule
7 billion live probiotic bacteria with Dual Coating (10 bioactive strains*) and 7.5 mg of prebiotic fibre in every capsule, vitamins (B1, B5, B2, B6, B12, B3, C, E); trace elements (calcium, phosphorous, magnesium, manganese, iron, zinc).
Instructions: 1/3 capsules per day for the first five days, followed by two capsules a day.

Fast - action 10 small vials
7 billion live probiotic bacteria with Dual Coating (10 bioactive strains*) and 458,24 mg of prebiotic fibre in every vial, vitamins (B1, B5, B2, B6, B12, B3, C, E); trace elements (calcium, phosphorous, magnesium, manganese, iron, zinc).

Instructions: one vial per day.

Vials for children with B. infantis and B. adolescentis
7 billion live probiotic bacteria with Dual Coating (12 bioactive strains*) and 458,24 mg of prebiotic fibres in every vial, vitamins (B1, B5, B2, B6, B12, B3, C, E); trace elements (calcium, phosphorous, magnesium, manganese, iron, zinc).
Instructions: one vial per day.

 

*Selected strains suitable for human consumption; registered  and present on the list of American Generally Recognized as Safe (GRAS) (Bifidobacterium bifidum, Propionobacterium Shermani, Streptococcus thermophilus, Lactobacillus bulgaricus, Lactobacillus casei, Lactobacillus plantarum, Lactobaciluus acidophilus, Lactobacillus lactis, Lactobacillus ramnosus, Lactobacillus helveticus, Lactobacillus infantis (in Ferzym Junior), Lactobacillus adolescentis (in Ferzym Junior).

THE TECHNOLOGICAL INNOVATION OF
DUAL-COATING: GUARANTEED STABILITY AND MAXIMUM BIOAVAILABILITY

A priobiotic is “an alimentary integrator with a base of live and vital micro-organisms that produce favourable effects on the body, by improving intestinal microbic balance” (Fuller, 1989)

Lactic acid bacteria commonly used in probiotic preparations have a limited shelf life mainly due to humidity and temperatures that inhibit product preservation. Indeed, the survival curve dips quickly, indicating that the number of live probiotic bacteria decrease rapidly over time.
 

Another weakness of these micro-organisms is their elevated sensitivity to gastrointestinal conditions that leads to a strong decrease in the initial microbic load.

Dual Coat technology, with its double protective proteic and oligosaccharidic layer (from plant proteins) that entirely cover probiotic bacteria, not only increases the lactic acid bacteria survival rate at room temperature and normal storage conditions, but it also provides superior and intense resistance to the negative conditions bacteria encounter when passing through the gastrointestinal tract.

 

Chart: non Dual Coated lactic acid bacteria after only 30 minutes at pH 2.1: initial load decreases by 80%.

 

Its particular resistance is caused by the varying solubility of the proteic film due to the different pH values encountered throughout the entire gastrointestinal system.

Dual Coated probiotics resist gastric and bile acid action thanks to the double protective proteic and oligosaccharidic layer which is insoluble in extreme pH conditions during the initial digestive process.

The proteic layer is insoluble to acidic pH, and protects the probiotic cells in the passage through the stomach so that they are freed intact in the intestine where they dissolve in the neutral pH.
The bacteria are then released in a live and vital state, ready to colonize immediately.

This means that there is a superior bioavailablity of the product which, in turn, leads to optimum colonization and maximum activity of the probiotic bacteria, and, as a consequence, guarantees their efficacy.

To this end, one of the parameters that has a strong influence on bioavailability of a product is its type of administration.
In fact, anything assumed via liquid form is much more easily and more quickly metabolised.

Liquid administration of a probiotic product is particularly advised for the treatment of acute infections, serious floral bacteria imbalances, and for those who suffer from inadequate intestinal absorption (in the elderly, colitis...).
Moreover, the Dual Coated technology provides documented resistance to high temperatures, which, especially during  summer months and in those climates most at risk, can cause a drastic reduction of the total microbic load in real terms of  live bacteria.

 

Chart: Dual-Coated lactic acid bacteria survival rate to gastric and bile acids, pH 2.1.
Note the excellent stability of Dual Coated bacteria at extreme temperatures, and two hours after consumption, the Dual-Coated probiotics remain numerous as they reach the intestine (with initial load decrease of 20%).

 

IMPORTANT ADVANTAGES OF DUAL COATED TECHNOLOGY

  • Maximum bio-availability
  • Maximum efficiency of action
  • Maximum resistance to gastrointestinal conditions
  • Maximum stability to negative environmental conditions (high temperatures, humidity)
  • Maximum stability during manufacture  process

  • AN INNOVATIVE FORMULATION OF PREBIOTIC COMPONENTS FROM SPECCHIASOL

    Prebiotic alimentary fibres consist of food substances that reach the digestive tract intact without undergoing any type of metabolic process. They reach the colon where they form a substratum that privileges certain types of bacteria while acting beneficially on the metabolism of bacterial flora and redressing imbalances of the flora. This favours the growth of bacteria healthy to the human body and that fight against problems resulting from imbalanced flora composition.
    Diet has a very important role in the development of intestinal microflora. Specifically, food rich in soluble fibres modify the type and quantity of microbes in the intestines.
    In collaboration with university research departments, Specchiasol has selected the best fibres available and mixed them in a special way to formulate a pool of quality fibres that is both effective and innovative.

    Inulin: Chicory Sugar

     

    Inulin is a water soluble polysaccharide present in many plants. It is extracted naturally and mainly from the chicory root, which is considered the best source of carbohydrates. In the United States it has been given the GRAS denomination (“Generally Recognized as Safe”), that is, it is safe for human consumption.
    Inulin resists both acid hydrolysis and invasion by pancreatic enzymes, remaining unaltered in the intestinal tract, where it is used as a selected nutritional source for probiotic bacteria.
    This explains why inulin does not increase glycaemia, nor does it influence the level of insulin in the blood, thus making its assumption possible among diabetics as well.
    Moreover, inulin has a very low calorie count (1kcal/g) precisely because it does not get digested until it reaches the colon due to the probiotic bacteria that feed on it.
    Depending on the length of the polysaccharide chain, inulin begins fermentation at various points along the intestine. The shorter sugars are metabolized in the first parts of the tract, while the more complex sugars reach the more distal areas.
    Hence, inulin promotes probiotic bacterial activity along the entire intestinal route.

    A study conducted by Gibson et. al. (1995) provides clear evidence that chicory sugars modify the composition of intestinal microflora thus favouring the species Bifidobacterium and Lactobacillus.

    The stimulation of the latter produces numerous health advantages, including:

    • Protection against cancer of the colon/rectum and intestinal infections caused by putrefied microflora (E. Coli, Clostridium, Salmonella, Listeria and Shigella)
    • Production of bacteriocins
    • Strengthening of the immune system
    • Synthesizing of Group B vitamins and proteolytic enzymes
    • Better absorption of selected minerals, including calcium and iron

    Moreover, inulin increases intestinal biomass, which promotes evacuation of the alvus – thereby inhibiting constipation. It also acts directly on the intestine, improving nutritional factors and strengthening the protective mucous. 
    Inulin is also important in the absorption of calcium ions normal in dietary intake. There are numerous studies that show a surprising increase in bioavailability and absorption of calcium by the body with an enriched diet of inulin. Absorption of the ions is real and consistent (not just in appearance) in that it leads to an effective mineralization of the bones and increases calcium content considerably: the benefits are obvious for women in menopause and for children and teenagers in their growth years.
    The metabolic routes that inulin takes are not currently known, but it is certain that it releases short chain fatty acids as a final product, including acetate, propionate and butyrate: the first two have anti - mycotic properties

     

    The degree of polymerization of sugar determines in which area of the colon fermentation takes place, by rapid metabolism of short molecules in the initial tract with a slower reaction on long molecules in more distal areas. The utilization of inulin and concomitant absorption of Ca take place therefore along the entire intestinal tract.

     

    Acacia: the prebiotic bifidogenic fiber 

    From the Papilionaceae family, the acacia plant thrives naturally in Africa and in northern Australia, where it has always been considered a symbol of vitality since it can grow in desert climes. It is a plant that produces thick and lush green fronds. Up to present times, it has been used in the preparation of anti-spastic and laxative herbal remedies, while in those areas where it grows, popular tradition has assigned it a role as a mouth freshener and as an anti-diarrhoea remedy because of the tannins and Vitamin P present in the trunk’s core. Gum arabic is extracted from incisions made in the branches of the variety A. nilotica, which is known for the presence of collagen that is widely used in cosmetics.

    Recent medical and scientific studies have shown the efficacy of its alimentary fibre and results have been very interesting: such as to consider it one of the most healthiest prebiotics currently known.
    The best Acacia fibre available is really a mixture of polysaccharides, taken from the exudate of  Acacia bark using physical methods that require no chemical or enzymatic modification.  
    A recent, in vivo, control-case, medical study by T. Kravtchenco entitled “Gastrointestinal Tolerance of Acacia Fibre When Assumed Daily” has demonstrated the complete digestibility of the polysaccharide substratum, in that patients had no flatulence or swelling, even after elevated doses of substratum (>70g/daily).

    The same cannot be said for other FOS, polysaccharides commonly used as prebiotics which provoke symptoms of flatulence and swelling in 80% and 40% (respectively) of cases even in small doses (>30g/daily).

    In conclusion, the difference between acacia fibre and other FOS is its specific bifidogenic activity, that is, its role in selectively stimulating the growth of the genus Bifidobacterium.

    BAOBAB: The Analeptic Prebiotic Fiber

    Baobab (Adansonia digitata L.) is a deciduous tree belonging to the Bombacacee family originally from central Africa. Its names probably derives from the Arab “bu habib”, meaning the fruit with many seeds.
    The leaves, bark and fruits have been traditionally used for food and medicinal applications, thus its nomenclature “little pharmacy”, thanks to the presence of different substances used in popular African medicine in the treatment of many pathologies.
    The pulp of the fruit is used as an anti-fever remedy, an analgesic and as an anti-inflammatory, due to the presence of liquid sterole extract, saponins and triterpene, and as an anti-diarrhoea/anti-dysentery remedy for its tannins (astringent) and mucilage and cellulose (liquid absorbing agent).
    The pulp of the Baobab fruit contains: 75.6% of total glucides, including glucose, fructose, saccharose, malt sugar, water-soluble polysaccharides and starch; 2.3 % of proteins, including amino acids among which, lysine, isoleucine, leucine, methionine, phenylalanine, threonine, histidine, tryptophan; numerous organic acids, including citric, tartaric, malic and succinic acids that give the acidic taste to the fruit.
    The Andasonia fruit is also extremely rich in Vitamin C (up to 300 mg/100g of pulp), riboflavin (vitamin B2), niacin (vitamin B3), and in selected essential minerals and fatty acids such as calcium (an average of 293 mg/100g), potassium (2.31 mg/100g), phosphorus (96-118 mg/100g) and linolenic (27 μg/g in dry weight), oleic and palmitic acids. 
    Thanks to the elevated levels of soluble fibre and reducing sugars, the pulp of the fruit has significant prebiotic properties that stimulate the growth of bifidobacteria typical in intestinal microflora.
    In addition, studies were carried out the pulp of the fruit at the Università Sacro Cuore in Piacenza (Italy) that demonstrated the bifidogenic effect on B. Longum, due to its specific polysaccharidic component.
    The same results were obtained for other species of bacteria isolated in the intestine, namely, B. infantis and B. bifidum.
    The same studies showed, using the same methods, an increase of 30% of growth of fecal Lattobacilli and a drastic decrease of the genus Clostridium, from which a potential inhibitory role can be discerned in pathogenic and putrescent microflora of Baobab fibre.
    The use of Baobab fibre in the formulation of a symbiotic is particularly advantageous not only for its obvious prebiotic properties, but also for its extraordinary functional properties.
    With its elevated quantity of amino acids, minerals and vitamins, it is best used, above all, in post-antibiotic regimes when it is necessary to redress the flora bacterial balance of the intestine while also being an indispensable nutritive component.

    VITAMIN AND MINERAL COMPOSITION OF FERZYM
         

    A combination of trace elements, minerals and B group vitamins that are actively involved in many fundamental metabolic processes facilitate the rebalancing and maintenance of intestinal bacterial flora.

         

    Trace Elements and minerals

    Iron: Iron is fundamental for intense production of haemoglobin especially in cases of fatigue. A lack of iron can lead to a low rate of haemoglobin in the blood, and consequently, anaemia.
    Zinc: A lack of zinc can lead to a deficit in enzyme activity. It protects the cells from oxidative stress.
    Magnesium: Magnesium is present to a large extent in our bodies: more than half is in the bones. It is a cofactor of numerous enzymes which use ATP and other triphosphate nucleotides. It is recommended in the treatment of mood disturbances, anxiety, for pre-menstrual symptoms and gastrointestinal dysfunction.
    Phosphorous: Phosphorous is involved in the metabolism of calcium and consequently has a fundamental role in all syndromes linked to this biochemical process.
    Calcium: It has a structural role in that it is present for 99% as phosphates in bone tissue. It is to be found in extracellular liquid while in a minor quantity in cellular cytoplasm.

    Vitamin B Complex

    Vitamin B1 (Thiamine): regulates energy from glucose. A lack of this component can lead to neurological dysfunction.
    Vitamin B2 (Riboflavin): acts an intermediary in the transfer of electrons in many redox reactions of the respiratory chain.
    Vitamin B6 (Pyridoxine): this vitamin complex is transformed in vivo into pyridoxal phosphate, a co-enzyme in numerous reactions of transamination and the decarbonating process of amino acids.
    Vitamin B12 (cobalamin): it has a fundamental enzymic role in the nervous system. A lack of cobalamin can manifest itself through neurological disturbances.
    Vitamin PP (niacin): it is involved in the synthesis of selected hormones and is essential to growth.
    Panthothenic Acid: it is the precursor to Co-enzyme A, which is indispensable for cell life, both for microorganisms and for all vegetable and animal tissue.

       
     

     

     

     




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